Sarah Joseph M.S., CSCS

Workout Blog

ACSM Topics: From Fat Metabolism to Heart Attacks

Posted by Sarah on June 1, 2013 at 1:25 PM

ACSM Indianapolis was great and I wanted to share some of the things that I learned. Here are some of the notes that I took. I apologize that there are no citations. I'm sorry. But I tried to make up the notes such that they are easily read and understood. 

 

Integrative control of skeletal muscle fat metabolism: impact of dietary intake

Featured science session

University of Copenhagen

Lorraine turcotte

Regulation of f.a. Metabolism

Fatty acid availability- When exercising at 85% vo2 max, fatty acid concentrations are reduced. This is because blood flow to adipose tissue is reduced. Less blood flow to fatty acid tissue causes the fatty acid coming out of adipose tissue to be reduced. However, during recovery after high intensity exercise, fatty acid oxidation increases.

Fatty acid uptake- cd36 and fappm , The higher the intensity, the higher the fatty acid uptake is, until you reach a certain level of intensity, then fatty acid uptake goes down.

  • Cd36 is a fatty acid transporter, involved in f.a. Uptake during muscle contraction.
  • Fabp is a fatty acid transporter whose level is increased with contraction, fatty acid uptake increases following the increase in cd 36 and fabp

Just because you increase fatty acid uptake, that doesn’t mean that you increase fatty acid oxidation. CPT1 is very important for fatty acid oxidation.

 

Healthy living through lifestyle: beyond pills and procedures

A very low fat, natural food diet combined with regular exercise is effective for treating many of the risk factors associated with cardiovascular artery disease, including hyperlipidemia, insulin resistance, type 2 diabetes, hypertension metabolic syndrome and inflammation.

 

A cardio protective polypill

Risk factors are being under treated.

Statin, frolic acid, aspirin, 3 BP drugs - 80% risk reduction

A poly pill may be good for ppl with known cardiovascular disease, and ppl for those over 55.

Limitations to a cardioprotective polypill.

- Don't know about interactions between drugs, mostly assumed to be additive

- Ignored conventional risk factors, smoking, obesity, sedentary activity

- Aspirin component could lead to hemmorage


 

10 year difference in lifespan between smokers and non-smokers

Obesity and age of first non st segment elevation MI- the higher the BMI of the patient, the lower the age that the patient experienced their first MI (MI- myocardial infartction)

Low cardiovascular fitness increases relative risk of all-cause mortality compared to being fit. Unfit ppl are 3 to 5 times to die in follow up after MI rather than fit counter parts regardless of weight. There was a bigger difference between for and unfit than smoker and unsmoker for risk for all-cause mortality.

For each 1 MET increase in exercise capacity (this is a way to measure cardiovascular fitness), there was a 16% decrease in cardiovascular risk which compares more favorably to statins following MI.

 

 


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